In this work, we test the efficacy of B-PAC-1 in MCL and present evidence showing B-PAC-1 has the ability to directly activate pro-casp3 to induce PCD in MCL cell lines via Zn sequestration and incubation of B-PAC-1 and Zn together significantly disrupt apoptotic program. Here, CASP3 is linked to mantle cell lymphoma.