PLCE1 and esophageal squamous cell carcinoma: PLCE1 protein was upregulated in 73.22% (82/112) of ESCC, 72.50% (28/40) of HGIN, 58.33% (35/60) of LGIN, and 2.03% (2/99) of normal epithelium, thereby indicating gradual increase in PLCE1 expression from the normal esophageal epithelium to ESCC (Supplementary Table 1, Figure 1B).