The results showed that the mean mRNA level of PLCE1 was threefold higher in ESCC samples than that in the corresponding normal esophageal epithelial tissues (0.006556 ± 0.0015 vs. 0.002051 ± 0.0007, P = 0.0108, Figure 1D). The gene discussed is PLCE1; the disease is esophageal squamous cell carcinoma.