PLCE1 and esophageal squamous cell carcinoma: Our previous research demonstrated that upregulation of PLCE1 is correlated with increased expression of NF-κB related proteins in Kazakh patients with ESCC [32], Our previous research demonstrated that PLCE1 upregulation is correlated with enhanced expression of NF-κB-related proteins in Kazakh patients with ESCC; hence, the interaction between PLCE1 and NF-κB signal pathway may be involved in ESCC carcinogenesis.