Moreover, GSK126 treatment also decreased the number of C4-2, PTEN-CaP8 and PC-3 PCa cells invaded through the matrix (Figure 3E and 3F), although these data cannot rule out the possibility that the effect of GSK126 on cell invasion can be attributed, at least in part, to GSK126-induced cell death (Figure 3B and 3D). This evidence concerns the gene PTEN and posterior cortical atrophy.