On the basis of our previous observations of cancer-related aberrations in intracellular iron homeostasis characterized by an altered expression of the transferrin receptor 1 (Tfrc), a main regulator of transferrin-bound iron uptake in mammalian cells during liver carcinogenesis [16], the goal of the present study was to investigate the underlying mechanisms associated with a cancer-related Tfrc dysregulation by using in vitro and in vivo models of liver carcinogenesis. Here, TFRC is linked to cancer.