CFL2 and breast cancer: Considering their gene ontology groupings, several proteins were potentially linked to the observed changes in invasiveness: The genes encoding Integrin-αV, a transmembrane protein involved in breast cancer metastasis and proliferation [19–21], N-WASP, a protein involved in signaling from cell membrane receptors to the actin cytoskeleton [34–36], Rac1, a cell motility-regulating Rho-GTPase involved in cancerogenesis [16,37] and Cofilin-2, a protein modulating actin reorganization and thus cell motility [38] were downregulated upon pre-miR-142-3p transfection, as confirmed by qPCR (Fig 2A–2D).