CHKA protein expression was frequently increased in PCa (12% positive cases in non-neoplastic [NN] benign prostate compared with 36% positive cases in PCa; P < .001) (Figure 1G; Supplementary Figure 2F, available online) and showed some evidence of association with Gleason grade (≤ vs 7) and tumor stage (pT2 vs pT3). This evidence concerns the gene CHKA and posterior cortical atrophy.