In a panel of AR-positive PCa cells, CHKA knockdown caused inhibition of androgen-stimulated growth comparable with the effects of AR knockdown but had only a modest effect on the growth of AR-null PCa cells PC3 and DU145 PCa cells and normal prostate epithelial PNT1a and RWPE-1 cells (Figure 4C; Supplementary Figure 4, B and C, available online). Here, AR is linked to posterior cortical atrophy.