Correlation analysis revealed that auranofin IC50 values were significantly correlated with TXNRD enzymatic activity levels in lung cancer cell lines (r = 0.78, P = 0.007), demonstrating that endogenous TXNRD1 levels in tumor cells are inversely associated with auranofin's activity (Figure 3B, 3C). The gene discussed is TXNRD1; the disease is neoplasm.