It has been well documented that Cyclooxygenase-2 (COX-2), as one of the VEGF/VEGFR-2 signaling client proteins, plays a central role in the modulation of angiogenesis, and our previous study found CS-6 suppressed COX-2 expression in non-small cell lung cancer (NSCLC) cells. Here, PTGS2 is linked to non-small cell lung carcinoma.