Recurrent aphthous ulcers, oral mucositis, oral lichen planus and other oral inflammatory disorders are generally associated with parasecretion of various pro-inflammatory cytokines (e.g., TNF-α, IL-1β, IL-6, IL-8, etc.)33, 34, 35, 36, 37. The gene discussed is CXCL8; the disease is canker sore.