GAB2 and ovarian cancer: Elevated levels of CXCL1 and CXCL8 in serum, ascites and tumors have been associated with poor prognosis and shorter survival in patients with ovarian cancer.20, 21, 30 We showed that suppression of CXCL1/2 or CXCL8 significantly inhibited proliferation and clonogenic growth of GAB2-transformed FTSECs and ovarian cancer cells.