We evaluated the efficacy of several small-molecule inhibitors against inhibitor of nuclear factor kappa-B kinase subunit β (IKKβ) on suppressing GAB2-induced chemokine expression and showed that combinatorial inhibition of IKKβ and PI3K/mTOR was more effective in suppressing proliferation and survival of GAB2-dependent ovarian cancer cells than individual inhibition. Here, GAB2 is linked to ovarian carcinoma.