PIK3CA and ovarian neoplasm: Our prior study showed that GAB2 is amplified and/or overexpressed in approximately one-third of primary HGSOCs.4 We and others observed that ovarian cancer cell lines overexpressing GAB2 are sensitive to PI3K inhibition.4, 14 This study revealed an important role of GAB2 overexpression in promoting ovarian tumor growth and angiogenesis by upregulating IKKβ-dependent expression of CXCL1, CXCL2 and CXCL8.