The paracrine signaling network induced by CXCL1/2 has recently been linked to cancer chemoresistance and metastasis in breast cancer.22 Further study is required to evaluate whether targeting CXCR2 or IKKβ alone will exhibit anti-angiogenic activity and also augment the efficacy of chemotherapy against ovarian cancer. The gene discussed is CXCR2; the disease is ovarian cancer.