CXCL1 and ovarian cancer: Tumor cells actively release pro-angiogenic factors such as vascular endothelial growth factor to promote endothelial cell proliferation, survival and migration for the formation of new blood vessels.28 In corroboration with previous findings showing that CXCL1 and CXCL8 are potent pro-angiogenic factors frequently upregulated in ovarian cancer,20, 21 we showed that CXCR2 blockade by antagonist SCH527123 completely inhibited the tube formation of HUVECs induced by ovarian cancer cells.