To examine whether high GAB2 levels in ovarian cancer cells are required for expression of CXCL1, CXCL2 and CXCL8, we suppressed GAB2 with inducible shRNAs in FUOV1 cells and observed that induced suppression of GAB2 decreased the mRNA levels of CXCL1, CXCL2 and CXCL8 compared with un-induced cells (Figure 2c). The gene discussed is CXCL8; the disease is ovarian carcinoma.