Consistent with the primary analysis shown in Fig. 2, proportional expression of group A (gpA1) was positively associated with retinopathy (p = 0.02, Fig. S2a) while group B(b1) and C(c2) were negatively associated with retinopathy (p = 0.03, p = 0.009 respectively, Fig. S2d,e). Here, CGA is linked to retinal disorder.