UBTF and liver cancer: Intriguingly, we found that knockdown of UBF depletion leads to an increase of euchromatic marks H3K4me3 across the ribosomal DNA promoter in human liver cancer cell (Fig. 6A), This is not due to the increased level of H3K4me3 as UBF knockdown does not result in any significant change of H3K4me3 level in HepG2 cell line (Supplementary Figure S1).