INS and Insulin resistance: Our findings are somewhat in contrast to previous studies demonstrating greater collagen deposition in skeletal muscle from obese insulin-resistant adults1 and increased muscle collagens 1 and 3 expression after 20 weeks HFD in mice.3 The mice used in these studies did not exhibit significant impairments in insulin sensitivity or glucose homeostasis and if the HFD was successful in generating insulin resistance as in previous mouse studies,3,4 the ECM markers measured may have better mimicked the human condition.