This observation is in line with previously published data: (1) Infection of HBV tg mice with adenovirus, murine cytomegalovirus, or lymphocytic choriomeningitis virus [30,31] as well as (2) direct administration of cytokines [32–35] or immunomodulatory substances including the TLR-9 ligand CpG [34,36] reduces the HBV titer. Here, TLR9 is linked to infection.