Considering that murine epithelia cells not expressing PON2 show a reduced ability to counteract P. aeruginosa infection [17], it has been hypothesized that its physiological role may be attenuation of pathogens infection, such as P. aeruginosa, by N-(3-oxododecanoyl)-L-homoserine lactone (3OC12-HSL) hydrolysis. This evidence concerns the gene PON2 and infection.