GTF2I and hereditary disease: Williams-Beuren syndrome, a complex multisystemic genetic disorder characterized by a unique cognitive profile and craniofacial defects, results from a small deletion at the chromosomal location 7q11.23 that encompasses, among other genes, GTF2I, GTF2IRD1 and GTF2IRD2, encoding three members of TFII-I family of transcription factors [1].