IL13RA2 and central nervous system cancer: For further validation of IL-13Rα2-dependent infectivity of Ad5FFscFv47-CMV-GFP, we performed an analysis of viral transduction in U87MG and U25MG cell lines, as well in patient-derived primary GBM43 and GBM39 glioma cells, which endogenously express IL13Rα2 at different levels (Fig. 4d).