The multivariate analysis showed that ECOG PS (HR 2.430, 95% CI 1.823–3.238, p < 0.001), BCL2-938C>A (CC vs. CA, HR 2.006, 95% CI 1.462–2.752, p < 0.001; CC vs. AA, HR 2.322, 95% CI 1.558–3.461, p < 0.001; CC vs. CA+AA, HR 2.096, 95% CI 1.555–2.824; p < 0.001), and BAX-248G>A (GG vs. GA, HR 1.632, 95% CI 1.210–2.199, p = 0.001; GG vs. AA, HR 2.014, 95% CI 1.188–3.425, p = 0.010; GG vs. GA+AA, HR 1.705, 95% CI 1.283–2.266, p < 0.001) were all independent predictors for OS of these NSCLC patients. The gene discussed is BAX; the disease is non-small cell lung carcinoma.