Recently, BAX-248G>A (rs4645878) was reported to be associated with reduced expression of BAX protein and altered susceptibility to chronic lymphocytic leukemia25, 26, although a meta-analysis of seven independent studies with 1772 cases and 1708 controls revealed that neither allele frequency nor genotype of BAX-248G>A associated with risk of human cancer using different genetic models54. Here, BAX is linked to cancer.