TBK1 is essential for the survival of non-small cell lung cancers driven by oncogenic KRAS9, 10, 11; this synthetic lethal interaction of TBK1 with mutant K-Ras was governed by its ability to activate NFκB anti-apoptotic signalling through c-Rel and BCL-XL. This evidence concerns the gene TBK1 and non-small cell lung carcinoma.