Notably, inhibition of TBK1 activity by treatment of NSCLC cells with BX795 (Fig. 4b,c), or shRNA-directed knockdown of TBK1 (Fig. 4d,e, Supplementary Fig. 7), affected mitosis and the association of CEP170 with centrosomes. The gene discussed is TBK1; the disease is non-small cell lung carcinoma.