For example, people with Loewy’s-Dietz syndrome caused by increased signaling through the TGFβ1 receptor have higher rates of food allergy [42] and connective tissue disorders such as Marfan’s syndrome in which there is also increase TGFβ1 signaling, associates with EoE [43]. This evidence concerns the gene TGFB1 and eosinophilic esophagitis.