SIRT1 and type 2 diabetes mellitus: There are an increasing number of papers assessing the relationship between SIRT1 and AMD in animal and in vitro studies.17,18,42 rs12778366 located in the promoter region of SIRT1 gene and has been studied in the schizophrenia, type 2 diabetes, systemic lupus erythematosus, glucose tolerance, and longevity patients.20,25,43,44 Lots of studies showed rs12778366 is a possible functional SNP in SIRT1 gene.