CFH and age-related macular degeneration: Linkage and association studies have implicated genetic modulators of AMD risk related to many mechanistic pathways, including oxidative stress, complement system dysregulation, DNA repair, mitochondrial dysfunction, neovascularization, and microglial recruitment.32 Researchers have tried to find genetic determinants for AMD and have proved that SNPs of many genes (eg, CFH,33 ARMS2,34 ELN,35 SKIV2L36) associated with AMD.