CHI3L1 and hepatocellular carcinoma: In fact, multiple-clinical indicators have been found to be strongly related to the prognostic outcomes prediction in patients with HCC.12–14 For example, previous studies have suggested that serum YKL-40,15 serum hyaluronic acid,16 or serum GGT17 might be useful for the prediction of HCC prognosis and for OS and RFS prediction in those patients receiving resection or undergoing radiofrequency ablation treatment.