Following, with the confirmed value of AUC, Hs-CRP showed a obviously better discriminatory ability as a potential indicator for OS screening of HCC patients when compared with age (AUC, 0.605; 95% CI, 0.548–0.694; P < 0.001), AFP (AUC, 0.667; 95% CI, 0.589–0.744; P < 0.001), ALT (AUC, 0.594; 95% CI, 0.513–0.674; P < 0.001), glutamyltranspeptidase (GGT) (AUC, 0.611; 95% CI, 0.563–0.703; P < 0.001), while was in the range of Child-Pugh class (AUC, 0.847; 95% CI, 0.755–0.912; P = 0.443). The gene discussed is AFP; the disease is hepatocellular carcinoma.