Recent studies have suggested that certain concentration changes in CRP level may contribute harmful prognostic outcomes in patients with various malignancies.7 With respect to HCC, previous evidence has proved that preoperative serum CRP level was detected to be increased that might eventually associated with aggressive tumor progression and poor prognostic outcomes in patients with HCC.7,8 However, very few studies were focused on the relationship between serum highly sensitive-CRP (Hs-CRP) levels and the prognostic outcomes of HCC in Chinese population. This evidence concerns the gene CRP and neoplasm.