TSHR and obesity due to melanocortin 4 receptor deficiency: TSH receptor could also play an important role in adipocyte differentiation and adipogenesis, resulting in obesity in mice and increasing BMI in humans.29 TSH could stimulate lipolysis in cultured adipocytes and elevate serum-free fatty acid levels in vivo.30 Besides, the involvement of leptin activation,31 visceral obesity32 and insulin resistance could also be relevant.33 Our study might shed some new light on the pathophysiological role of TSH on lipid in clinical perspective.