Mild hypothyroidism represents early thyroid failure, which is usually progressive, especially when TSH is higher than 10 μIU/mL, in females and with positive thyroid peroxidase antibodies.24,25 Hypothyroidism is associated with greater cardiovascular risk factors, including hyperlipidemia,1,11,26,27 making it an important topic in people's health. The gene discussed is TPO; the disease is hypothyroidism.