There is considerable evidence indicating that high PCT levels are related to infection in cirrhosis.9,29 However, the accuracy of using PCT levels for the early detection of infection, especially for SBP, in ESLD patients is controversial.30–31 In some studies, serum PCT levels were reported to diagnose SBP with satisfactory sensitivity and specificity, whereas in others the diagnostic values were doubtful. This evidence concerns the gene CALCA and Cirrhosis.