NAT2 and lung cancer: N-acetyltransferase 2 (NAT2) gene, located on the short arm of chromosome 8 (8q22), encodes a phase II xenobiotic-metabolizing enzyme.6,7NAT2 gene is essentially involved in the metabolism of aromatic, heterocyclic amines, and hydrazines.8,9 Five known polymorphisms in NAT2 gene, namely C282T, A803G, C481T, G590A, and G857A, are associated with decreased enzyme activity and variable stability, leading to imbalance of the process of xenobiotics detoxification and consequently affecting lung cancer susceptibility.10