For example, some studies have shown that TRPM2 has a protective role in sepsis, cardiovascular injury, Listeria monocytogenes-induced liver damage, and endotoxin-induced pulmonary inflammation27, while other studies have indicated that TRPM2 plays a detrimental role in such disorders as chemically-induced colitis, ischemia, and diabetes22, 28, 35. Here, TRPM2 is linked to ischemia.