Specifically, 12-month-old infants who had IgG antibodies to CSP, SERA5, MSP142 (FVO), MSP142 (FUP), EBA140, EBA175, AMA1 (3D7), or AMA1 (FVO) had a statistically significant increased risk of infection (hazard ratio range, 2.64 to 6.21) compared to infants with negative serology at 12 months of age. This evidence concerns the gene DNAJC5 and infection.