This implies that dynamic regulation of actin stress fibers by cofilins is vital for the actin-LINC complex to control nuclear shape, movement, and integrity that is lost in an array of diseases, collectively termed as laminopathies (Dauer and Worman, 2009, Gundersen and Worman, 2013, Stewart et al., 2007). Here, CFL1 is linked to laminopathy.