Together with the observation that no abnormalities were observed in an in-depth histopathological analysis of adult C2βD1212A/D1212A mice, our data identify PI3K-C2β as a potential drug target for insulin sensitization in the treatment of insulin resistance in type 2 diabetes or non-alcoholic fatty liver disease. This evidence concerns the gene SCGB2B3P and type 2 diabetes mellitus.