Whereas PI3K-C2β inactivation did not affect body-weight increase (Figure 7A), C2βD1212A/D1212A mice showed a significant reduction in liver weight gain (Figure 7B), a significant protection against liver steatosis (Figure 7C) as well as reduced levels of neutral lipids (as documented by oil red O staining) and triglycerides in the liver (Figure 7D). This evidence concerns the gene SCGB2B3P and fatty liver disease.