Although MSKQLL1 and SCCQLL1 cells showed overexpression of various surface molecules related to low sensitivity to EGFR inhibition such as HER-2, -3, c-Met, and p53 and these overexpressions of EGFR resistance related signals may explain the reason of nearly complete resistance to cetuximab of both cell lines, all of the oral cancer cells analyzed in this study, interestingly, showed intense expression of NF-κB. This evidence concerns the gene TP53 and lip and oral cavity carcinoma.