Significantly upregulated CXCL12 and CXCR4 expression was detected in the uteri of IFN-γ-induced abortion mice in vivo, and CXCL12 facilitated peripheral CD49b+ NK cell migration in vitro (data not shown), suggesting an association between CXCL12 and IFN-γ-induced abortion. This evidence concerns the gene IFNG and abortion.