NCAM1 and acute myeloid leukemia: However, neither FAS nor TNF-α death pathways seem to be involved in the induction of NK cell apoptosis and depletion since NKCAs are not affected by caspase blockade.[14] In addition, the CD56+CD16- NK cell subset undergoes AML cell-induced apoptosis to the same extent as the CD56+CD16+ NK cell subset.