Indeed, there was a positive correlation between 88 kDa progranulin expression and marked cell death in NGR-peptide-1-treated AML blasts (Figure 11B); conversely, the expression of the 105 kDa isoform was associated with AML blast resistance to NGR-peptide-1 (Figure 11B). This evidence concerns the gene RTN4R and acute myeloid leukemia.