Recently, Lawan et al. demonstrated an increase in hepatic lipogenesis and inhibition of CREB-mediated glucogenesis in liver-specific Dusp1 knock-out mice, which indicate that Dusp1 also contributes to steatosis including ALD and nonalcoholic fatty liver disease (NAFLD) [33]. This evidence concerns the gene CREB1 and metabolic dysfunction-associated steatotic liver disease.