Total glutathione S-transferase placental form (GST-P) positive areas including GST-P positive foci (diameter > 200 μm) as preneoplastic lesions, HCA and HCC were increased in Tg rats as compared to those in Wt rats regardless of EtOH intake, and tended to increase with EtOH intake only in Tg rats. The gene discussed is HPGDS; the disease is hepatocellular carcinoma.