For example, Mitra et al. identified the disrupted FFLs in NSCLC from a predicted, but reproducible, TF and miRNA regulatory network, and found that miR-9-5p and miR-130b-3p could inhibit the tumor-suppressive activity of TGF-β pathway by targeting a core regulatory molecule TGFBR2 [16]. This evidence concerns the gene TF and non-small cell lung carcinoma.