In the light of no available standard treatment for patients with translocational RCC, a mammalian target of rapamycin (mTOR) inhibitor (everolimus 10 mg daily) counteracting phosphorylation of TFEB by mTOR complex 1 (mTORC1) [6] and denosumab (120 mg subcutaneously every fourth week), a monoclonal antibody regulating osteoclast activity by targeting the RANK ligand, were both applied during and after postsurgical radiotherapy. Here, TFEB is linked to renal cell carcinoma.