IGF1R and lung cancer: Nine transcripts were selected from the list of differentially expressed transcripts (SPC-IGFIR-Akt2−/− vs SPC-IGFIR) based on three criteria, (i) a fold change of at least 2, (ii) a p-value < 0.0002, and (iii) the gene had previously been implicated in human lung cancer (Table 3).