The SPC-IGFIR transgenic mouse model is relevant to lung cancer since IGF-IR is highly expressed in ∼95% of human SCLCs and ∼80% of NSCLCs [60–62] and high levels of Igf1r mRNA have been significantly associated with reduced overall survival and disease-free survival in NSCLC [63, 64]. This evidence concerns the gene IGF1R and lung cancer.