One could argue that this increase in Sftpc simply reflects the increased tumor burden found in the SPC-IGFIR-Akt2−/− mice however RNA-seq comparing lungs from wild type mice to SPC-IGFIR lung tumors found a significant, 2.5-fold reduction in SPC-IGFIR tumors compared to normal lung tissue (unpublished observations). The gene discussed is AKT2; the disease is neoplasm.