SFTPC and neoplasm: Thus, the enhanced Sftpc expression found in the SPC-IGFIR-Akt2−/− tumors could be due to an increase in the number of type II alveolar resulting from the loss of Akt2 or it could indicate that the tumor cells in the SPC-IGFIR-Akt2−/− mice are more differentiated and express higher levels of Sftpc than tumor cells in SPC-IGFIR mice.