MMP-2 has been shown to regulate NSCLC migration and metastasis and genes, [109–112] micro-RNAs [113, 114] or chemicals [115–117] have been shown to mediate their anti-migratory effects through negatively regulating MMP-2 as well as other matrix metalloproteinases such as MMP-9. This evidence concerns the gene MMP9 and non-small cell lung carcinoma.