We propose a new CML grading system for USH-RP patients, including comparative evaluation of CML between USH types and most frequent USH-associated genes, i.e. MYO7A and USH2A. Such a grading system would allow evaluation of USH-RP prognostic factors and treatment decisions in a very detailed way. The gene discussed is USH2A; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.