In the light of the limited data on the variants of the MTHFR and hypertension in our population, and the role of vitamin B2 in the improvement of blood pressure in hypertensive patients with a mutant variant of the MTHFR gene, this case–control study was carried out to investigate the association of 677C > T polymorphism of MTHFR with the risk of hypertension in a sample of the Moroccan population. The gene discussed is MTHFR; the disease is Hypertension.