BCL2 is overexpressed in approximately 40–65 % of DLBCL tumors, owing to t(14;18)(q32;q21) translocations found in 15–30 % of cases, and through additional mechanisms that are not well defined [75, 107, 144, 145, 360, 362, 365, 366]. Here, BCL2 is linked to diffuse large B-cell lymphoma.