A recent study performed by Hagner P.R. et al. demonstrated that CC-122, a novel immunomodulatory agent-like thalidomide analog, directly binds to CRBN and promotes ubiquitinylation and degradation of Aiolos and Ikaros in DLBCL in vitro, in vivo and in patients with relapsed/refractory DLBCL, resulting in a mimicry of lethal IFN type I signaling through direct de-repression of interferon-stimulated gene (ISGs) transcription and induction of interferon inducible proteins, and ultimately leading to apoptosis in DLBCL [300]. The gene discussed is CRBN; the disease is diffuse large B-cell lymphoma.