Deregulation of the PI3K/AKT/mTORC1 pathway by the inactivation of PTEN, an inhibitor of the PI3K/AKT/mTORC1 pathway, is found in 55 % of GCB-DLBCL cases, but only in 14 % of non-GCB-DLBCL and worsens prognosis [324]. This evidence concerns the gene PTEN and diffuse large B-cell lymphoma.