BCR/proliferation-DLBCL tumors also show increased expression levels of cell-cycle regulatory factors, (including CDK2 and MCM family members), DNA damage response signaling factors (such as PMS2 family members, H2AX, PTIP, and TP53) as well as higher levels of various essential B cell-specific transcription factors (such as BCL6, MYC, STAT6, PAX5, OBF1 and E2A). This evidence concerns the gene TP53 and diffuse large B-cell lymphoma.