PARP1 and cancer: Moreover, alterations in a variety of DNA repair and DNA damage signaling genes, such as ARTEMIS, DNA-PKS, KU80, KU70, CHECK2 or ARTD1/PARP1 that affect the MMR and/or NHEJ DNA repair pathways have been recently identified in DLBCL tumors and most likely also constitute intermediate cancer driver events in lymphomagenesis [23, 24].