Inhibition BET proteins by small molecules inhibitors CPI203 and JQ1 as well as siRNA-mediated depletion of BRD2 and BRD4 expression, attenuated oncogenic IKKβ signaling, thereby inhibiting downstream oncogenic NF-κB-driven transcriptional programs and killing ABC-DLBCL cells in vitro and in an ABC-DLBCL xenograft model [239]. The gene discussed is BRD4; the disease is diffuse large B-cell lymphoma.