The GCB-DLBCL subtype also frequently carries additional mutations affecting epigenetic modification such as mutations in genes encoding the histone acetyltransferases CREB-binding protein (CREBBP) and E1A-binding protein p300 (EP300) as well as the histone-lysine N-methyltransferase and myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2) [15, 19, 20, 29]. This evidence concerns the gene CREBBP and diffuse large B-cell lymphoma.