Our study showed that ARTD9 can inhibit the IFNγ/STAT1-dependent anti-proliferative and pro-apoptotic activities of tumor suppressor IRF1 while simultaneously activating the STAT1/IRF2-mediated anti-apoptotic-pro-survival pathways in HR-subtype DLBCL cells [470]. The gene discussed is IRF2; the disease is diffuse large B-cell lymphoma.