I-BET151, another novel highly selective inhibitor of both BRD2 and BRD4 causes transcriptional silencing of the c-MYC gene and c-MYC-dependent programs in myeloma cells by inhibition of BRD2 and BRD4 binding to the promoter of the c-MYC gene and failure to recruit P-TEFb and PAFc1 complexes to the IGH/c-MYC enhancer by BRD2 and BRD4, and lack of subsequent RNA-Pol-II recruitment [405]. Here, BRD4 is linked to plasma cell myeloma.