The first study identified three discrete DLBCL-NOS subsets defined by their unique transcriptional profiles (consensus cluster (CC) signature): Oxidative phosphorylation (OxPhos)-DLBCL, B-cell receptor (BCR)/proliferation (BCR)-DLBCL, and host-response (HR)-DLBCL [116]. The gene discussed is BCR; the disease is diffuse large B-cell lymphoma.