In contrast to OxPhos-DLBCL and BCR-DLBCLs, HR-DLBCL tumors are associated with a brisk, but ineffective host immune/inflammatory response and with a prominent T-cell/dendritic cell infiltrate as previously described for T/HRLBCL [46, 47, 116, 134]. This evidence concerns the gene BCR and diffuse large B-cell lymphoma.