Recent studies demonstrated that the proteolytic activity of mucosa-associated lymphoid tissue lymphoma translocation (MALT) protein-1 is required for the survival and pathogenesis of ABC- DLBCL with chronic active BCR signaling [270, 271] and therefore, represents another new potential therapeutic target in relapsed/refractory cases of the BCR-subtype of ABC-DLBCL [270]. The gene discussed is BCR; the disease is diffuse large B-cell lymphoma.