A subsequent study identified an oncogenic TYK2-STAT1 pathway in T-cell acute lymphoblastic leukemia (T-ALL) cell lines, mediated through gain-of-function TYK2 mutations or activation of IL10 receptor signaling, that leads to the upregulation of BCL2 and T-ALL cell survival [468]. This evidence concerns the gene TYK2 and acute lymphoblastic leukemia.