However, it remains to be further investigated whether this proposed ARTD1 connected macroARTD(7–9)-DTX3L pathways and mechanisms do also exists in DNA-DSB repair proficient DLBCL, or may be restricted to DNA-DSB repair deficient solid cancer types and certain DNA-DSB repair deficient B and T lymphoid tumor types. This evidence concerns the gene PARP1 and diffuse large B-cell lymphoma.