Indeed, 10 % of DLBCL cases demonstrate nuclear NF-κB activity exclusively for the non-canonical pathway (indicated by nuclear staining of p52 but not p50) while 20 % of DLBCLs display nuclear staining for both p50 and p52 [18], strongly indicating that the concurrent activation of both canonical and non-canonical NF-κB pathways occurs in a large fraction of DLBCL [18, 27, 160]. Here, NFKB2 is linked to diffuse large B-cell lymphoma.