In line with the observation that the DTX3L and ARTD9 genes are located in a head-to-head orientation on chromosome 3q21, sharing the same bidirectional STAT1/IRF1 and STAT3-responsive promoter [469–471], DTX3L is mainly overexpressed in pSTAT1(Y701/S727)-positive HR-subtype GCB-DLBCL cells and pSTAT3(Y705/S727)-positive BCR-subtype ABC-DLBCL cells weekly expressing pSTAT1(Y701/S727) [470]. This evidence concerns the gene STAT3 and diffuse large B-cell lymphoma.