DDIT3 and diffuse large B-cell lymphoma: A subsequent phase I/II study of patients with previously untreated DLBCL investigating bortezomib in combination with R-CHOP demonstrated that the efficacy of bortezomib plus R-CHOP was similar in patients with non-GCB- and GCB-DLBCL, consistent with the concept that the unfavorable non-GCB-DLBCL subgroup with constitutive NF-κB overexpression derives benefit from bortezomib sensitization with chemotherapy [266] (Additional file 1: Table S3).