Signaling downstream of IL6 and IL10 in B-cell lymphoma involves primarily activation of JAK1/JAK2-STAT3 axis and to a lesser extend the JAK1/JAK2-STAT1 or TYK2-MAPK-STAT1 axis [313, 322, 323, 468]. The gene discussed is JAK2; the disease is B-cell non-Hodgkin lymphoma.