EZH2 and diffuse large B-cell lymphoma: Several recent preclinical studies demonstrated that potent and selective S-adenosyl-methionine-competitive small molecule inhibitors of EZH2 such as E7438 (EPZ-6438), GSK-126 or CPI-360 eliminate tumor growth in GCB-DLBCL models with activating EZH2 mutations [77, 354–356].