NFKB1 and diffuse large B-cell lymphoma: HR-DLBCL was identified by a microenvironment gene expression signature and is associated with increased expression of inflammatory mediators, such as multiple components of the T-cell receptor (TCR), molecules associated with T/NK-cell activation and the complement cascade, downstream targets of IFNγ and/or IFNγ/STAT1 signaling and upregulation of NF-κB pathways [116, 134].