SYK and arthritic joint disease: A greater role for SYK on disease induction has been reported in other models; in particular, genetic deficiency of Syk in the hematopoietic compartment completely blocked the development of arthritis in the K/BxN serum-transfer murine model [35] and Coffey et al. [19] reported PRT062607 to dose-dependently reduce the development of paw inflammation in a murine CAIA model.