HERC5 and hepatocellular carcinoma: Then in another independent HCC patient cohort [35], after adjustment for age, gender, and HBV status, HERC5 under-expression was associated with shorter overall survival (p = 0.02; HR = 3.31 CI95 = [1.22, 8.96]) and PFS (p = 0.01; HR = 3.80 CI95 = [1.38, 10.43]) (Fig. 3c; Table 2).