CCL20 and neoplasm: CCL20 has been shown to be the only chemokine significantly up-regulated in HCC tissue [50], where it can selectively recruit Tregs to the tumor, contributing to an immunosuppressive tumor microenvironment and leading to poor prognosis in HCC [51, 52], Both the genetic basis and mechanism for the source of highly secreted CCL20 in HCC still remains to be elucidated.