Unlike multiple transcriptomic studies that have developed gene signatures to predict tumor recurrence or survival in HCC [7–25], HERC5 was not solely identified as a statistical correlate with outcome, rather, this gene is located within a large somatic copy number deletion on chromosome 4q in both PTs and RTs and was suppressed in HCC patients who experienced tumor recurrence, compared to those who did not. Here, HERC5 is linked to hepatocellular carcinoma.