By studying the whole transcriptome expression profile of the HCC cell line PLCPRF5 with HERC5 siRNA knockdown, CCL20 was the most over-expressed transcript (fold = 5.8), and genes coding classic regulators of CCL20 such as TNF, NFKB1, or TRIM32 showed no change (Additional file 1: Table S10, Additional file 2). The gene discussed is CCL20; the disease is hepatocellular carcinoma.