Interestingly, a global knock-in of a single SUMO mutation (K289R) in mouse LRH-1, which is equivalent to K270R in hLRH-1, has no strong phenotype on its own, but mitigates aortic plaque formation in Ldlr-/- arteriosclerosis-prone mice (Stein et al., 2014). The gene discussed is NR5A2; the disease is arteriosclerosis disorder.