Staining of mTOR in the tumor center correlated with p-mTOR (r = 0.195, p = 0.028; Additional file 4: Figure S3b), and there was a positive association MMP2 with MMP9 at the invasive front (r = 0.214, p = 0.015; Additional file 4: Figure S3c). This evidence concerns the gene MMP9 and neoplasm.