TNC and cancer: It should be noted that cancer-fibroblast cell interaction leads to a “fibrillar” organization of extracellularely deposited Tn-C, However, this is not a real fibrillogenesis but is due to a molecular interaction of tenascin-C with other molecules including fibrillary, therefore we interpret the “fibril like” stromal depositions as “tubular matrix channels” or “vasculogenic mimicry [21–23].