Single gene diseases that may present with stroke or transient ischemic attack (TIA), include Fabry’s disease (FD) [5], a rare X-linked inborn error of glycosphingolipids metabolism, caused by mutations in the alpha-galactosidase A (GLA) gene, resulting in the reduced production of the enzyme α-galactosidase A. In FD, the enzymatic deficiency leads to lysosomal accumulation of neutral glycosphingolipids in all tissues, particularly in vascular endothelial cells [6]. The gene discussed is GLA; the disease is stroke disorder.