GLA and ischemic stroke: This patient had a profound decrease of alpha-galactosidase A activity in plasma and leukocytes, and an increased concentration of lyso-Gb3 in plasma; and a woman, included for recurrent ischemic stroke, who carried the D313Y GLA gene variant, commonly defined as polymorphism and reportedly associated with lower alpha-galactosidase A level in plasma and normal GLA enzyme activity in leukocytes, causing the so called “pseudodeficiency” [36].