PDGFRB and cancer: Another compelling mechanism involving a possible role of ANK3 in cancer pathogenesis is presented by an elegant work by Ignatiuk et al. [36] where it was demonstrated that smaller isoforms of ANK3, called ANK120 and ANK105, were able to bind the PDGFR-binding subunit of PI3K, p85, influencing the lysosomal degradation of the receptor.