KNG1 and blood coagulation disease: One of the most important cause is the addition of heparin to blood flow during CPB to prevent clotting, coagulation disorders such as underlying disease, von-Willebrand, high thin blood, Immaturity of the liver, especially in infants and delays in the clearance of heparin and decreased levels of factor XII and XI, Prekallikrein and Kininogen wurth high molecular weight (Chang, Hanley, Vernowsky, & Wessel, 1990).