Loss‐of‐functionmutations in the GnRH1 receptor and deficiency of GnRH I (GNRH1, P01148) are associated withhypogonadotropic hypogonadism although some ‘loss of function’ mutations may actuallyprevent trafficking of ‘functional’ GnRH1 receptors to the cell surface,as evidenced by recovery of function by nonpeptide antagonists [1061]. Here, GNRH1 is linked to hypogonadism.