Studies in ratsand mice (including wildtype, and relaxin‐3 and RXFP3 gene‐deletion strains[671, 782, 1759, 1971] have revealed putativeroles for the relaxin‐3/RXFP3 system in the modulation of feeding [564, 566, 714, 1706, 1760], anxiety [1618, 2114], and reward andmotivated, goal‐directed behaviours [782, 1619, 1971], particularly in relationto the integration of stress and corticotrophin‐releasing factor signalling[1162], with implications forthe therapeutic treatment of clinical anxiety, depression, eating disorders andaddiction (see [565, 1761] for review). This evidence concerns the gene RXFP3 and Anxiety.