To explore the roles of Hes1 in colon cancer cells, we examined Hes1 expression levels in 6 colon cancer cell lines using quantitative RT-PCR and found high Hes1 expression levels in CaCo2 and SW48 cells and low Hes1 expression levels in HCT116 cells (Fig 1A). This evidence concerns the gene HES1 and colonic neoplasm.